Jennette J C, Eifrig D E, Paranjape Y B
J Am Intraocul Implant Soc. 1982 Winter;8(1):35-7. doi: 10.1016/s0146-2776(82)80008-6.
Polymethylmethacrylate intraocular-lens-implanted rabbits were challenged with subcutaneous polymeric or monomeric methylmethacrylate. The inflammatory response to this secondary challenge was compared to that at the site of sham procedures and to that in control rabbits never exposed to methylmethacrylate. There was a definite granulomatous inflammatory response to both polymeric and monomeric methylmethacrylate. There was, however, no secondary enhancement of this inflammatory response at the site of subcutaneous challenge or exacerbation of intraocular inflammation in lens-implanted rabbits, thus substantiating the nonimmunogenicity of methylmethacrylate.
给植入聚甲基丙烯酸甲酯人工晶状体的兔子皮下注射聚合态或单体态的甲基丙烯酸甲酯。将这种二次激发所引发的炎症反应与假手术部位的炎症反应以及从未接触过甲基丙烯酸甲酯的对照兔子的炎症反应进行比较。对聚合态和单体态甲基丙烯酸甲酯均有明确的肉芽肿性炎症反应。然而，在皮下激发部位，这种炎症反应并未出现二次增强，在植入晶状体的兔子中眼内炎症也未加重，从而证实了甲基丙烯酸甲酯的非免疫原性。
