聚甲基丙烯酸甲酯人工晶状体中的甲基丙烯酸甲酯单体。细胞毒性。

Methylmethacrylate monomer in intraocular lenses of polymethylmethacrylate. Cellular toxicity.

作者信息

Turkish L, Galin M A

出版信息

Arch Ophthalmol. 1980 Jan;98(1):120-1. doi: 10.1001/archopht.1980.01020030122012.

DOI:10.1001/archopht.1980.01020030122012

Abstract

Tissue cultures of secondary rabbit kidney cells were grown in maintenance medium containing varying concentrations of methylmethacrylate monomer from 5% to 0.05%. No pathologic changes were observed in those tissue cultures containing 0.1% or less monomer as compared to controls. Data from previous studies on the rate of elution of monomer from polymethylmethacrylate and from published studies of aqueous humor dynamics indicate that the monomer level in intraocular lenses will be less than the concentration toxic to living cells in tissue culture.

摘要

将兔肾传代细胞培养于含有浓度从5%至0.05%不等的甲基丙烯酸甲酯单体的维持培养基中。与对照组相比，那些含有0.1%及以下单体的组织培养物未观察到病理变化。先前关于聚甲基丙烯酸甲酯中单体洗脱速率的研究数据以及已发表的房水动力学研究表明，人工晶状体中的单体水平将低于组织培养中对活细胞有毒的浓度。