Yoshikawa T, Yamaguchi K, Kondo M, Mizukawa N, Ohta T, Hirakawa K
Arch Gerontol Geriatr. 1982 Nov;1(3):209-18. doi: 10.1016/0167-4943(82)90022-x.
Thiobarbituric acid (TBA) reactive substances in serum and cerebrospinal fluid from patients with cerebral apoplexy were determined and their relationship to this disease was studied. TBA reactants in serum were elevated in patients with cerebral apoplexy, but there was no difference between patients with brain tumor or other neurological disease and healthy persons. TBA reactants in cerebrospinal fluid in patients with cerebral aneurysm, cerebral arterial and venous anomalies or intracerebral hematoma, and its levels in patients with cerebral infarction or brain tumor were also higher than in healthy persons. Serum alpha-tocopherol levels were elevated in patients with cerebral infarction, but were relatively low in patients with cerebral aneurysm, cerebral arterial and venous anomalies or intracerebral hematoma. The reverse was the case with cerebrospinal fluid levels of alpha-tocopherol. That is, the sequence of decreasing level of alpha-tocopherol in cerebrospinal fluid was intracerebral hematoma, cerebral aneurysm, cerebral arterial and venous anomalies, and cerebral infarction. The levels of TBA reactive substances in patients with cerebral apoplexy showed a positive correlation between serum and cerebrospinal fluid, and the levels of alpha-tocopherol showed a similar correlation.
测定了脑中风患者血清和脑脊液中的硫代巴比妥酸（TBA）反应性物质，并研究了它们与该疾病的关系。脑中风患者血清中的TBA反应物升高，但脑肿瘤或其他神经系统疾病患者与健康人之间无差异。脑动脉瘤、脑动静脉畸形或脑内血肿患者脑脊液中的TBA反应物，以及脑梗死或脑肿瘤患者脑脊液中的TBA反应物水平也高于健康人。脑梗死患者血清α-生育酚水平升高，但脑动脉瘤、脑动静脉畸形或脑内血肿患者血清α-生育酚水平相对较低。脑脊液中α-生育酚水平情况则相反。即脑脊液中α-生育酚水平由高到低的顺序为脑内血肿、脑动脉瘤、脑动静脉畸形、脑梗死。脑中风患者血清和脑脊液中TBA反应性物质水平呈正相关，α-生育酚水平也呈类似的相关性。
