肌萎缩侧索硬化症患者脑脊液中α-生育酚的水平
Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis.
作者信息
de Bustos F, Jiménez-Jiménez F J, Molina J A, Esteban J, Guerrero-Sola A, Zurdo M, Ortí-Pareja M, Tallón-Barranco A, Gómez-Escalonilla C, Ramírez-Ramos C, Arenas J, Enríquez de Salamanca R
机构信息
Department of Biochemistry, Hospital Universitario Doce de Octubre, Madrid, Spain.
出版信息
J Neural Transm (Vienna). 1998;105(6-7):703-8. doi: 10.1007/s007020050089.
We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 30 patients with sporadic amyotrophic lateral sclerosis (SALS) and 78 matched controls. The mean CSF and serum vitamin E levels did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal versus bulbar) of SALS. CSF alpha-tocopherol levels did not correlate with age, age at onset, and duration of the disease. These results suggest that CSF and serum alpha-tocopherol concentrations are unrelated with the risk for ALS.
我们比较了30例散发性肌萎缩侧索硬化症（SALS）患者和78例匹配对照者脑脊液（CSF）和血清中通过高效液相色谱法（HPLC）测定的α-生育酚（维生素E）水平及CSF/血清比值。两个研究组之间CSF和血清维生素E的平均水平无显著差异。这些值不受SALS临床类型（脊髓型与延髓型）的影响。CSF中α-生育酚水平与年龄、发病年龄及病程均无相关性。这些结果表明CSF和血清中α-生育酚浓度与患ALS的风险无关。
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