DeLucia R, Lara P F, Valle L B, Oliveira-Filho R M
Acta Physiol Lat Am. 1981;31(4):235-9.
A six-compartment model is proposed to study hippuran kinetics in several tissues and body fluids. This comprises plasma (in which the tracer is introduced), extravascular space (anatomically not defined), kidneys (left and right), "delay" (the dead space through which the urine passes from kidneys to the bladder) and the cumulative urinary excretion. Based on accurate internal measurements of radioactivity, theoretical values which reproduced the experimental data have been fitted to a SAAM program. A good fit was observed between the curves. This study is intended to be of value for better understanding and use of tests for clinical evaluation of renal function.
提出了一种六室模型来研究马尿酸在几种组织和体液中的动力学。该模型包括血浆（向其中注入示踪剂）、血管外间隙（未明确解剖定义）、肾脏（左肾和右肾）、“延迟”（尿液从肾脏到膀胱所经过的死腔）以及累积尿排泄量。基于对放射性的精确内部测量，已将重现实验数据的理论值拟合到SAAM程序中。观察到曲线之间拟合良好。本研究旨在为更好地理解和使用肾功能临床评估测试提供价值。
