Distribution and kinetics of hippuran 131I in rats.

A six-compartment model is proposed to study hippuran kinetics in several tissues and body fluids. This comprises plasma (in which the tracer is introduced), extravascular space (anatomically not defined), kidneys (left and right), "delay" (the dead space through which the urine passes from kidneys to the bladder) and the cumulative urinary excretion. Based on accurate internal measurements of radioactivity, theoretical values which reproduced the experimental data have been fitted to a SAAM program. A good fit was observed between the curves. This study is intended to be of value for better understanding and use of tests for clinical evaluation of renal function.