Smeraldi E, Gasperini M, Macciardi F, Bussoleni C, Morabito A
J Psychiatr Res. 1982;17(3):309-17. doi: 10.1016/0022-3956(82)90010-3.
We analyzed the age-at-onset distributions in a group of 285 patients diagnosed as having major affective disorder, recurrent, either unipolar or bipolar, in order to detect the possible existence of genetic and epidemiological factors affecting their age-at-onset distribution. In fact, since it is known that affective disorders are genetically heterogeneous with respect to the liability systems involved, methodological considerations support the hypothesis of the existence of different ages at onset also. We thus investigated several variables and the significant findings of our study were that bipolarity, at least one affected parent and a low position in the sibship are each associated with earlier age at onset of affective disease.
我们分析了285名被诊断为患有复发性重性情感障碍（单相或双相）患者的发病年龄分布情况，以检测可能影响其发病年龄分布的遗传和流行病学因素。事实上，由于已知情感障碍在涉及的易患性系统方面存在遗传异质性，方法学上的考虑也支持存在不同发病年龄的假设。因此，我们研究了几个变量，我们研究的重要发现是双相情感障碍、至少有一位患病父母以及在兄弟姐妹中排行靠后均与情感疾病的较早发病年龄相关。
