Acritopoulou S, Haresign W
J Reprod Fertil. 1980 Jan;58(1):219-21. doi: 10.1530/jrf.0.0580219.
Six groups of 4 ewes were given a single i.m. injection of 100 microgram ICI 80,996 on Days 3, 5, 8, 11, 14 or 16 of the oestrous cycle. On day 3 treatment was only partly effective in causing luteal regression, with only 2 of the 4 treated ewes returning to oestrus. Injection had no apparent effect when given on Day 16, at a time when luteal regression had already started naturally. However, treatment between Days 5 and 14 inclusive of the oestrous cycle evoked a rapid fall in progesterone concentrations to basal values of less than 0.5 ng/ml within 24 h with a high degree of synchrony in the return of oestrus (37.7 +/- 1.6 h) and the timing of the LH peak (45.3 +/- 3.2 h) after injection. We conclude that the corpus luteum of the ewe is responsive to ICI 80,996 only between Days 5 and 14 of the oestrous cycle.
在发情周期的第3、5、8、11、14或16天，将6组，每组4只母羊，进行一次100微克ICI 80,996的肌肉注射。在第3天进行治疗时，引起黄体退化的效果仅部分有效，4只接受治疗的母羊中只有2只恢复发情。在第16天注射时没有明显效果，此时黄体已经开始自然退化。然而，在发情周期的第5天至第14天（含第5天和第14天）之间进行治疗，会使孕酮浓度在24小时内迅速降至低于0.5纳克/毫升的基础值，发情恢复（37.7±1.6小时）和注射后促黄体生成素峰值时间（45.3±3.2小时）具有高度同步性。我们得出结论，母羊的黄体仅在发情周期的第5天至第14天对ICI 80,996有反应。
