双胞胎血清高密度脂蛋白的遗传度研究
On the heritability of serum high density lipoprotein in twins.
作者信息
Sistonen P, Ehnholm C
出版信息
Am J Hum Genet. 1980 Jan;32(1):1-7.
Abstract
To estimate the relative contributions of hereditary vs. environmental factors in the variation of high density lipoprotein, we measured the concentrations of its main apoprotein components, apoprotein A-I (apo A-I) and apoprotein A-II (apo A-II), in serum samples from 65 monozygotic (MZ) and 70 dizygotic (DZ) like-sexed twin pairs. Evidence for a genetic component of variance was found for apo A-II, giving heritability (h2) estimates of .35 and .30 for males and females, respectively. No genetic contribution to the variance of apo A-I could be demonstrated. Additionally, males had lower concentrations of apo A-I, but higher of apo A-II, than females.
摘要
为了评估遗传因素与环境因素对高密度脂蛋白变化的相对贡献，我们测量了65对同卵（MZ）和70对异卵（DZ）同性双胞胎血清样本中高密度脂蛋白主要载脂蛋白成分，即载脂蛋白A-I（apo A-I）和载脂蛋白A-II（apo A-II）的浓度。发现apo A-II存在方差的遗传成分证据，男性和女性的遗传率（h2）估计值分别为0.35和0.30。未证明apo A-I的方差存在遗传贡献。此外，男性的apo A-I浓度低于女性，但apo A-II浓度高于女性。
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