Itoh Z, Honda R, Aizawa I
Am J Physiol. 1980 Feb;238(2):G91-6. doi: 10.1152/ajpgi.1980.238.2.G91.
Continuous measurements of intraduodenal pH changes were made in five healthy conscious dogs by means of a miniature pH electrode inserted into the duodenum through a chronically implanted duodenal cannula. Gastric motor activity was also recorded simultaneously by means of a chronically implanted force transducer. When dogs were fed once a day with a measured volume of dog food, it was found that 24-h pH changes in the duodenal contents could be divided into three major periods: the weak acid period, the strong acid period, and alkaline period. The weak acid period lasted for 9.2 +/- 0.43 h after feeding with the duodenal pH ranging from 7.0 to 4.0. The weak acid period was gradually changed to the strong acid period in which the duodenal pH fluctuated widely from 8.0 to 1.0. This period lasted for 5.2 +/- 0.26 h. After the strong acid period, pH of the duodenum abruptly turned alkaline and remained between 7.0 and 8.3 until the next meal. These three periods of pH change are closely related to those of three different gastric motor patterns; the digestive, intermediate, and interdigestive patterns, respectively.
通过一根经长期植入的十二指肠套管插入十二指肠的微型pH电极，对5只清醒的健康犬进行十二指肠内pH变化的连续测量。同时，通过长期植入的力传感器记录胃运动活动。当每天给犬喂食一定量的狗粮时，发现十二指肠内容物的24小时pH变化可分为三个主要阶段：弱酸期、强酸期和碱性期。喂食后，弱酸期持续9.2±0.43小时，十二指肠pH值在7.0至4.0之间。弱酸期逐渐转变为强酸期，在此期间十二指肠pH值在8.0至1.0之间大幅波动。这个阶段持续5.2±0.26小时。强酸期过后，十二指肠pH值突然变为碱性，并保持在7.0至8.3之间，直至下一餐。这三个pH变化阶段分别与三种不同的胃运动模式密切相关，即消化模式、中间模式和消化间期模式。
