Lane R J, Gardner-Medwin D, Roses A D
Neurology. 1980 May;30(5):497-501. doi: 10.1212/wnl.30.5.497.
Electrocardiographic (ECG) abnormalities characteristic of Duchenne muscular dystrophy (tall R waves in the right precordial leads and deep Q waves in the lateral chest leads) are rarely observed in carriers, but Emery (1969) found that the (R-S) amplitude sum in lead V1 was significantly greater in carriers than in age-matched controls. In a prospective single-blind study, we analyzed coded records from 11 carriers and 12 age-matched normal women for (R-S) amplitude sums and R/S ratios in leads V1 and V2. Values in carriers were significantly greater for all these characteristics, discrimination being most marked for R/S in V2 (p less than 0.01). This was confirmed in a further retrospective study, comparing records from 18 carriers with 100 normal ECGs from women of the same age range. Density functions for (R-S) in V1 and the R/S ratio in V2 derived from carrier and normal population can be incorporated into probability calculations to determine risk of carrier status.
杜氏肌营养不良的心电图（ECG）异常特征（右胸前导联R波高尖，外侧胸导联Q波深）在携带者中很少见，但埃默里（1969年）发现，携带者V1导联的（R-S）振幅总和显著高于年龄匹配的对照组。在一项前瞻性单盲研究中，我们分析了11名携带者和12名年龄匹配的正常女性的编码记录，以获取V1和V2导联的（R-S）振幅总和及R/S比值。携带者的所有这些特征值均显著更高，V2导联的R/S差异最为明显（p<0.01）。在另一项回顾性研究中得到了证实，该研究比较了18名携带者的记录与同年龄范围女性的100份正常心电图。来自携带者和正常人群的V1导联（R-S）及V2导联R/S比值的密度函数可纳入概率计算，以确定携带者状态的风险。
