用合成的胞壁酰二肽与海藻糖二霉菌酸酯混合物对实验性癌症进行免疫治疗。
Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate.
作者信息
Yarkoni E, Lederer E, Rapp H J
出版信息
Infect Immun. 1981 Apr;32(1):273-6. doi: 10.1128/iai.32.1.273-276.1981.
Abstract
The antitumor activity of a mixture of synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and trehalose-6,6'-dimycolate (TDM) (MDP+TDM) in emulsified form was studied in guinea pigs, each with a syngeneic dermal tumor and microscopically detectable metastases in regional lymph nodes. A single intralesional administration of an ultrasonically prepared emulsion containing MDP+TDM in squalane or in mineral oil caused tumor regression and elimination of lymph node metastases. Similar emulsions of MDP+TDM made with squalene or hexadecane were immunotherapeutically inactive.
摘要
在豚鼠中研究了乳化形式的合成N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）和海藻糖-6,6'-二霉菌酸酯（TDM）（MDP + TDM）混合物的抗肿瘤活性，每只豚鼠都患有同基因皮肤肿瘤且在局部淋巴结中有显微镜下可检测到的转移灶。在角鲨烷或矿物油中单次瘤内注射含有MDP + TDM的超声制备乳液可导致肿瘤消退并消除淋巴结转移。用角鲨烯或十六烷制成的MDP + TDM类似乳液没有免疫治疗活性。
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本文引用的文献
1
Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.用合成的胞壁酰二肽和海藻糖二霉菌酸酯治疗后豚鼠肿瘤的消退。
Science. 1980 Apr 25;208(4442):415-6. doi: 10.1126/science.7189295.
2
Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs.油的类型和表面活性剂浓度对乳化的牛分枝杆菌卡介苗细胞壁诱导豚鼠肿瘤消退功效的影响。
Infect Immun. 1980 Jun;28(3):881-6. doi: 10.1128/iai.28.3.881-886.1980.
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Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.合成的N-乙酰胞壁酰肽或氨基酸的免疫佐剂活性。
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Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
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