用合成的胞壁酰二肽与海藻糖二霉菌酸酯混合物对实验性癌症进行免疫治疗。
Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate.
作者信息
Yarkoni E, Lederer E, Rapp H J
出版信息
Infect Immun. 1981 Apr;32(1):273-6. doi: 10.1128/iai.32.1.273-276.1981.
Abstract
The antitumor activity of a mixture of synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and trehalose-6,6'-dimycolate (TDM) (MDP+TDM) in emulsified form was studied in guinea pigs, each with a syngeneic dermal tumor and microscopically detectable metastases in regional lymph nodes. A single intralesional administration of an ultrasonically prepared emulsion containing MDP+TDM in squalane or in mineral oil caused tumor regression and elimination of lymph node metastases. Similar emulsions of MDP+TDM made with squalene or hexadecane were immunotherapeutically inactive.
摘要
在豚鼠中研究了乳化形式的合成N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）和海藻糖-6,6'-二霉菌酸酯（TDM）（MDP + TDM）混合物的抗肿瘤活性，每只豚鼠都患有同基因皮肤肿瘤且在局部淋巴结中有显微镜下可检测到的转移灶。在角鲨烷或矿物油中单次瘤内注射含有MDP + TDM的超声制备乳液可导致肿瘤消退并消除淋巴结转移。用角鲨烯或十六烷制成的MDP + TDM类似乳液没有免疫治疗活性。
相似文献
1
Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate.用合成的胞壁酰二肽与海藻糖二霉菌酸酯混合物对实验性癌症进行免疫治疗。
Infect Immun. 1981 Apr;32(1):273-6. doi: 10.1128/iai.32.1.273-276.1981.
2
Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.用合成的胞壁酰二肽和海藻糖二霉菌酸酯治疗后豚鼠肿瘤的消退。
Science. 1980 Apr 25;208(4442):415-6. doi: 10.1126/science.7189295.
3
Comparison of muramyl dipeptide, trehalose dimycolate, and dimethyl dioctadecyl ammonium bromide as adjuvants in Brucella abortus 45/20 vaccines.布鲁氏菌45/20疫苗中胞壁酰二肽、海藻糖二霉菌酸酯和二甲基二十八烷基溴化铵作为佐剂的比较。
Infect Immun. 1980 Nov;30(2):409-12. doi: 10.1128/iai.30.2.409-412.1980.
4
Modulation of natural killer cytotoxicity by muramyl dipeptide and trehalose dimycolate incorporated in squalane droplets.角鲨烷液滴中所含的胞壁酰二肽和海藻糖二甲酯对自然杀伤细胞细胞毒性的调节作用。
Cancer Immunol Immunother. 1987;24(1):19-24. doi: 10.1007/BF00199828.
5
Enhancement of endotoxic shock by N-acetylmuramyl-L-alanyl-(L-seryl)-D-isoglutamine (muramyl dipeptide).
Cancer Res. 1979 Nov;39(11):4756-9.
6
Stimulation of chemiluminescence and resistance against aerogenic influenza virus infection by synthetic muramyl dipeptide combined with trehalose dimycolate.合成的胞壁酰二肽与海藻糖二霉菌酸酯联合使用对化学发光的刺激作用及对空气传播型流感病毒感染的抵抗力。
Infect Immun. 1984 Jan;43(1):233-7. doi: 10.1128/iai.43.1.233-237.1984.
7
9
Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs.油的类型和表面活性剂浓度对乳化的牛分枝杆菌卡介苗细胞壁诱导豚鼠肿瘤消退功效的影响。
Infect Immun. 1980 Jun;28(3):881-6. doi: 10.1128/iai.28.3.881-886.1980.
引用本文的文献
1
Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor.膳食面包酵母使荷瘤小鼠的 Ehrlich 乳腺癌对紫杉醇敏感。
Oncol Rep. 2019 Jun;41(6):3155-3166. doi: 10.3892/or.2019.7107. Epub 2019 Apr 10.
2
MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion.MSU 晶体增强 TDB 介导的炎症性巨噬细胞 IL-1β 分泌。
Inflammation. 2019 Jun;42(3):1129-1136. doi: 10.1007/s10753-019-00976-5.
3
Squalene emulsions for parenteral vaccine and drug delivery.用于肠胃外疫苗和药物递送的角鲨烯乳剂。
Molecules. 2009 Sep 1;14(9):3286-312. doi: 10.3390/molecules14093286.
4
Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil.在可代谢油中与抗原一起给予胞壁酰二肽衍生物后，细胞介导的和抗体免疫反应持续增强。
Infect Immun. 1981 Jul;33(1):312-4. doi: 10.1128/iai.33.1.312-314.1981.
5
Muramyl peptides. Chemical structure, biological activity and mechanism of action.胞壁酰肽。化学结构、生物活性及作用机制。
Mol Cell Biochem. 1981 Dec 4;41:27-47. doi: 10.1007/BF00225295.
6
A specific vaccine effective against stage I and stage II malignant disease in guinea pigs. Effect of variations in preparations and storage.一种对豚鼠I期和II期恶性疾病有效的特定疫苗。制剂和储存变化的影响。
Cancer Immunol Immunother. 1982;14(2):92-5. doi: 10.1007/BF00200174.
7
Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections.胞壁酰二肽的合成衍生物L18-MDP（丙氨酸）对小鼠抗微生物感染非特异性抵抗力的影响。
Infect Immun. 1982 Jul;37(1):292-300. doi: 10.1128/iai.37.1.292-300.1982.
8
Inhibition of tumor growth in mice treated with synthetic muramyl dipeptide.用合成的胞壁酰二肽处理的小鼠中肿瘤生长的抑制
Cancer Immunol Immunother. 1984;18(2):123-5. doi: 10.1007/BF00205746.
9
Antitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma.免疫佐剂肽聚糖单体PGM对荷MCa乳腺癌小鼠的抗肿瘤和抗转移活性
Cancer Immunol Immunother. 1984;18(1):49-53. doi: 10.1007/BF00205399.
10
Stimulation of chemiluminescence and resistance against aerogenic influenza virus infection by synthetic muramyl dipeptide combined with trehalose dimycolate.合成的胞壁酰二肽与海藻糖二霉菌酸酯联合使用对化学发光的刺激作用及对空气传播型流感病毒感染的抵抗力。
Infect Immun. 1984 Jan;43(1):233-7. doi: 10.1128/iai.43.1.233-237.1984.
本文引用的文献
1
Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.用合成的胞壁酰二肽和海藻糖二霉菌酸酯治疗后豚鼠肿瘤的消退。
Science. 1980 Apr 25;208(4442):415-6. doi: 10.1126/science.7189295.
2
Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs.油的类型和表面活性剂浓度对乳化的牛分枝杆菌卡介苗细胞壁诱导豚鼠肿瘤消退功效的影响。
Infect Immun. 1980 Jun;28(3):881-6. doi: 10.1128/iai.28.3.881-886.1980.
3
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.细菌肽聚糖衍生物佐剂活性的最小结构要求。
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25. doi: 10.1016/0006-291x(74)90458-6.
4
A guinea pig model for tumor immunology. A summary.肿瘤免疫学的豚鼠模型。综述。
Isr J Med Sci. 1973 Mar;9(3):366-74.
5
Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.合成的N-乙酰胞壁酰肽或氨基酸的免疫佐剂活性。
Biken J. 1975 Jun;18(2):105-11.
6
Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
Int J Cancer. 1977 Jun 15;19(6):818-21. doi: 10.1002/ijc.2910190612.
7
Enhancement of endotoxic shock by N-acetylmuramyl-L-alanyl-(L-seryl)-D-isoglutamine (muramyl dipeptide).
Cancer Res. 1979 Nov;39(11):4756-9.
Zotero 插件