Martin W J, Gipson T G, Martin S E, Rice J M
Science. 1976 Oct 29;194(4264):532-3. doi: 10.1126/science.973137.
A transplacentally induced lung tumor of strain C3Hf mice grows progressively when transplanted to (C3Hf X A)F1 hybrid mice but not when transplanted to C3Hf recipients. Progressive tumor growth occurs in [(C3Hf X A)F1 X C3Hf] backcross mice inheriting the H-2a haplotype from the F1 parent. Furthermore, radioresistant immunity to the lung tumor can be induced in C3Hf mice by immunization with normal tissue of B10.A and B10.A(2R) but not of B10 or B10.A(5R) strain mice.
C3Hf品系小鼠经胎盘诱导产生的肺肿瘤，移植到（C3Hf×A）F1杂交小鼠时会逐渐生长，但移植到C3Hf受体小鼠时则不会。从F1亲本继承H-2a单倍型的[（C3Hf×A）F1×C3Hf]回交小鼠中会出现肿瘤的逐渐生长。此外，用B10.A和B10.A（2R）品系小鼠的正常组织免疫C3Hf小鼠，可诱导出对肺肿瘤的放射抗性免疫，而用B10或B10.A（5R）品系小鼠的正常组织免疫则不能。
