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一种金黄仓鼠品系中肝脏胆固醇酯储存异常。胆固醇代谢研究的可能模型。

Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism.

作者信息

Sable-Amplis R, Sicart R, Agid R

出版信息

Biochim Biophys Acta. 1978 Nov 22;531(2):215-21. doi: 10.1016/0005-2760(78)90145-5.

DOI:10.1016/0005-2760(78)90145-5
PMID:718971
Abstract

Very high values of hepatic cholesteryl esters were found in a strain of golden hamsters isolated in our laboratory: 2 g/100 g in animals kept at 22 degrees C and more than 10 g/100 g in starved cold-adapted animals. The rate of incorporation of labelled mevalonate was not increased, but the esterification of the newly-synthetized cholesterol was markedly stimulated.

摘要

在我们实验室分离出的一种金黄仓鼠品系中发现肝脏胆固醇酯含量极高

在22摄氏度饲养的动物中为2克/100克，在饥饿的冷适应动物中超过10克/100克。标记甲羟戊酸的掺入率并未增加，但新合成胆固醇的酯化作用受到显著刺激。

相似文献

1
Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism.一种金黄仓鼠品系中肝脏胆固醇酯储存异常。胆固醇代谢研究的可能模型。
Biochim Biophys Acta. 1978 Nov 22;531(2):215-21. doi: 10.1016/0005-2760(78)90145-5.
2
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The effect of acyl CoA: cholesterol acyltransferase inhibition on the uptake, esterification and secretion of cholesterol by the hamster small intestine.
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Lipid composition and lipogenic activities in the livers of normo- and hereditary hyperlipidemic chickens.正常和遗传性高脂血症鸡肝脏中的脂质组成和脂肪生成活性
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[Effect of ethynyl estradiol and estradiol dipropionate on the esterification of saturated and unsaturated fatty acids in the rat liver].[乙炔雌二醇和雌二醇二丙酸酯对大鼠肝脏中饱和及不饱和脂肪酸酯化作用的影响]
Vopr Med Khim. 1987 Mar-Apr;33(2):77-83.

引用本文的文献

1
Cholesterol gallstone induction in hamsters reflects strain differences in plasma lipoproteins and bile acid profiles.仓鼠胆固醇胆结石的诱发反映了血浆脂蛋白和胆汁酸谱的品系差异。
Lipids. 1993 Apr;28(4):305-12. doi: 10.1007/BF02536315.
2
Absence of cholesterogenesis regulation in the liver and prostate of the BIO 87.20 hamster.BIO 87.20仓鼠肝脏和前列腺中胆固醇生物合成调节的缺失。
Lipids. 1981 Nov;16(11):835-40. doi: 10.1007/BF02535039.
3
Marked elevation of HDL-cholesterol in cold-adapted golden hamsters.冷适应金黄地鼠中高密度脂蛋白胆固醇显著升高。
Experientia. 1986 Feb 15;42(2):153-5. doi: 10.1007/BF01952442.