一种金黄仓鼠品系中肝脏胆固醇酯储存异常。胆固醇代谢研究的可能模型。
Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism.
作者信息
Sable-Amplis R, Sicart R, Agid R
出版信息
Biochim Biophys Acta. 1978 Nov 22;531(2):215-21. doi: 10.1016/0005-2760(78)90145-5.
PMID:718971
Abstract
Very high values of hepatic cholesteryl esters were found in a strain of golden hamsters isolated in our laboratory: 2 g/100 g in animals kept at 22 degrees C and more than 10 g/100 g in starved cold-adapted animals. The rate of incorporation of labelled mevalonate was not increased, but the esterification of the newly-synthetized cholesterol was markedly stimulated.
摘要
在我们实验室分离出的一种金黄仓鼠品系中发现肝脏胆固醇酯含量极高
在22摄氏度饲养的动物中为2克/100克，在饥饿的冷适应动物中超过10克/100克。标记甲羟戊酸的掺入率并未增加，但新合成胆固醇的酯化作用受到显著刺激。
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