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冷适应金黄地鼠中高密度脂蛋白胆固醇显著升高。

Marked elevation of HDL-cholesterol in cold-adapted golden hamsters.

作者信息

Sicart R, Sablé-Amplis R, Bluthé E

出版信息

Experientia. 1986 Feb 15;42(2):153-5. doi: 10.1007/BF01952442.

DOI:10.1007/BF01952442
PMID:3456307
Abstract

Golden hamsters with spontaneous hypercholesterolemia at 22 degrees C developed a further increase in plasma cholesterol when they were maintained at 6 degrees C. This hypercholesterolemia was associated with a redistribution of plasma cholesterol between VLDL and HDL. Plasma cholesterol transported in the VLDL decreased while cholesterol in the HDL increased by 45%. The LDL profile was not significantly modified.

摘要

在22摄氏度下患有自发性高胆固醇血症的金黄地鼠,当饲养在6摄氏度时,其血浆胆固醇会进一步升高。这种高胆固醇血症与血浆胆固醇在极低密度脂蛋白(VLDL)和高密度脂蛋白(HDL)之间的重新分布有关。VLDL中运输的血浆胆固醇减少,而HDL中的胆固醇增加了45%。低密度脂蛋白(LDL)的情况没有明显改变。

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Comparative studies of the circulating lipoproteins in hamster (Mesocricetus auratus) with a normal or spontaneous high level of cholesterol in the plasma.对血浆胆固醇水平正常或自发升高的仓鼠(金黄地鼠)体内循环脂蛋白的比较研究。
Comp Biochem Physiol A Comp Physiol. 1984;78(3):511-4. doi: 10.1016/0300-9629(84)90587-5.
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Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism.一种金黄仓鼠品系中肝脏胆固醇酯储存异常。胆固醇代谢研究的可能模型。
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9
Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitro.体外极低密度脂蛋白脂解过程中高密度脂蛋白2样颗粒的形成。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4519-23. doi: 10.1073/pnas.75.9.4519.
10
Separation of plasma lipoproteins by density-gradient ultracentrifugation.通过密度梯度超速离心法分离血浆脂蛋白。
Anal Biochem. 1975 May 12;65(1-2):42-9. doi: 10.1016/0003-2697(75)90488-1.