Keirse M J, Sokolewicz J J, Frankena A, Jaszmann L
Eur J Obstet Gynecol Reprod Biol. 1980 May;10(4):231-7. doi: 10.1016/0028-2243(80)90003-9.
Labor was induced with oral prostaglandin (PGE2) without amniotomy in 20 patients (10 nulliparae and 10 multiparae) with hypertension, whether or not associated with edema and/or proteinuria. An average dose of 8 mg was required to achieve effective uterine contractility in both nulliparae and multiparae. Multiparae required only a mean dose of 12 mg but nulliparae a dose of 18 mg to achieve delivery. The mean duration of labor was slightly longer in both nulliparae and multiparae than that achieved with fast escalating doses of i.v. oxytocin. The need for analgesia was greater in oxytocin-induced patients than in the prostaglandin-induced patients. Otherwise no differences were found between the two groups.
对20例高血压患者（10例初产妇和10例经产妇）采用口服前列腺素（PGE2）引产，未行羊膜穿刺术，这些高血压患者无论是否伴有水肿和/或蛋白尿。初产妇和经产妇均平均需要8毫克剂量才能实现有效的子宫收缩。经产妇仅需平均12毫克剂量，但初产妇需要18毫克剂量才能分娩。初产妇和经产妇的平均产程均比快速递增剂量静脉滴注缩宫素引产的产程略长。缩宫素引产患者比前列腺素引产患者对镇痛的需求更大。除此之外，两组之间未发现差异。
