Sato I, Hasegawa Y, Hotta K
Pflugers Arch. 1980 Mar;384(1):1-7. doi: 10.1007/BF00589508.
Effects of pharmacological denervation with propranolol (0.2 mg.kg-1) and/or atropine (0.04 mg.kg-1) on the control system of heart rate during exercise were studied using a frequency domain analysis, to evaluate the cardiac control function of autonomic nervous systems in man. Propranolol decreased the gain of the system in low frequency range and increased the gain slightly in middle and high frequency ranges. The phase angle of the system was advanced over the whole frequency range observed. Atropine decreased and delayed the gain and phase angle, respectively, especially in high frequency range. The combined administration of blockades significantly decreased the gain and delayed the phase angle in the whole and high frequency ranges, respectively. These findings suggest that sympathetic and parasympathetic nervous systems act nearly independently in controlling heart rate during exercise; that they act in different manners; and that the characteristics of the systems can feasibly be used to estimate clinically the cardiac control function of autonomic nerves in man.
采用频域分析法研究了普萘洛尔（0.2mg·kg-1）和/或阿托品（0.04mg·kg-1）药物去神经支配对运动期间心率控制系统的影响，以评估人体自主神经系统的心脏控制功能。普萘洛尔降低了系统在低频范围内的增益，并在中高频范围内略有增加。在所观察的整个频率范围内，系统的相角提前。阿托品分别降低并延迟了增益和相角，尤其是在高频范围内。联合使用阻滞剂分别在整个和高频范围内显著降低了增益并延迟了相角。这些发现表明，交感神经和副交感神经系统在运动期间控制心率时几乎独立起作用；它们以不同的方式起作用；并且这些系统的特征可用于临床上评估人体自主神经的心脏控制功能。
