Wakayama Y, Schotland D L, Bonilla E
Neurology. 1980 Jul;30(7 Pt 1):740-8. doi: 10.1212/wnl.30.7.740.
Normal human quadriceps muscle was transplanted into nude mice subcutaneously for periods of 1, 2, 3, 4, 6, and 8 weeks. At 1 week, there was myoblast and myotube formation with thin and thick filaments. After 2 weeks, there was myotube formation with partially cross-striated myofilaments, and formation of dyads or triads. Leptomeres were also noted in some myotubes. By 4 weeks, cross-striation of myofilaments and migration of muscle nuclei to the periphery were observed. Distended sarcoplasmic reticulum and honeycomb structures of tubules were noted between 4 and 8 weeks. This study indicates that mature human muscle can be transplanted successfully into nude mice, providing another tool for the investigation of human neuromuscular disease.
将正常人类股四头肌皮下移植到裸鼠体内，移植时间分别为1、2、3、4、6和8周。在1周时，有肌母细胞和肌管形成，伴有粗细肌丝。2周后，有肌管形成，肌丝部分出现横纹，并有二联体或三联体形成。在一些肌管中也观察到细肌丝。到4周时，观察到肌丝出现横纹，肌细胞核向周边迁移。在4至8周期间，可见肌浆网扩张和小管呈蜂窝状结构。本研究表明，成熟的人类肌肉可以成功移植到裸鼠体内，为人类神经肌肉疾病的研究提供了另一种工具。
