Fóris G, Dezsö B, Medgyesi G, Bazin H
Int Arch Allergy Appl Immunol. 1981;65(2):138-43. doi: 10.1159/000232749.
High concentration of cytochalasin B (CB) and vinblastine (Vb) inhibited the erythrocyte-antibody (EA) rosette formation of rat peritoneal macrophages (PM). Low concentration of Vb enhanced rosette formation. CB and Vb had the same effect on the rosette formation when anti-SRBC immunoglobulin (Ig) had been previously bound in vivo or in vitro to the Fc receptors (FcR) of the macrophages, suggesting that the intact function of the cytoskeleton is required for the last step of rosette formation. CB and Vb exert a reversible effect on FcR activity. Regeneration of FcR activity was observed also in the presence of 10 microgram/ml cycloheximide. The effect of CB and Vb on rosette formation depends both on the (sub)classes of antibody involved and on the nature of the particulate antigen. Rosettes with living trypanosomes displayed an extremely high CB sensitivity.
高浓度的细胞松弛素B（CB）和长春花碱（Vb）抑制大鼠腹腔巨噬细胞（PM）的红细胞-抗体（EA）玫瑰花结形成。低浓度的Vb增强玫瑰花结形成。当抗绵羊红细胞免疫球蛋白（Ig）先前在体内或体外与巨噬细胞的Fc受体（FcR）结合时，CB和Vb对玫瑰花结形成具有相同的作用，这表明玫瑰花结形成的最后一步需要完整的细胞骨架功能。CB和Vb对FcR活性发挥可逆作用。在存在10微克/毫升环己酰亚胺的情况下也观察到FcR活性的再生。CB和Vb对玫瑰花结形成的影响既取决于所涉及抗体的（亚）类，也取决于颗粒抗原的性质。与活锥虫形成的玫瑰花结显示出极高的CB敏感性。
