[某些生理特征之间关系结构的遗传分析。II. 葡萄糖耐量指标与血浆胆固醇水平分析]

[Genetic analysis of the structure of relations between certain physiologic traits. II. Analysis of glucose tolerance indices and plasma cholesterol levels].

作者信息

Sergeev A S, Luchkina E M, Lunga I N, Mazovetskiĭ A G, Koshechkin V A

出版信息

Genetika. 1980;16(5):908-13.

PMID:7192241

Abstract

A genetic analysis of the characteristics of sugar curve (138 pairs) and cholesterol levels (CS) in the plasma (283) was carried out on a twin sample of 18-40 years old, taken from the Twin Register. Estimation of heritability were 0.66 for the sugar level in the blood before taking breakfast (S0), 0.5 for the sugar level 1 hour after taking 50 g of glucose (S1); 0.43 for the sugar level 2 hours after taking glucose (S2), and 0.38 for CS. There were genetic correlations between all the four characteristics, and they were 0.7 for S0-S1; 0.12 for S1-S2; 0.6 for S0-S2. Genetic correlation between the characteristics of sugar curve and the CS levels were 0.28 for CS-S0; 0.38 for CS-S1; 0.26 for CS-S2.

摘要

对取自双胞胎登记处的18至40岁双胞胎样本（138对）的血糖曲线特征和血浆中胆固醇水平（CS）（283例）进行了基因分析。早餐前血糖水平（S0）的遗传力估计值为0.66，摄入50克葡萄糖后1小时血糖水平（S1）的遗传力为0.5；摄入葡萄糖后2小时血糖水平（S2）的遗传力为0.43，CS的遗传力为0.38。这四个特征之间均存在遗传相关性，S0与S1之间的遗传相关性为0.7；S1与S2之间为0.12；S0与S2之间为0.6。血糖曲线特征与CS水平之间的遗传相关性，CS与S0之间为0.28；CS与S1之间为0.38；CS与S2之间为0.26。