Watanabe H, Nakano S, Ogawa N, Suzuki T
Biomed Mass Spectrom. 1980 Apr;7(4):160-3. doi: 10.1002/bms.1200070405.
A selected ion monitoring assay for apomorphine using N-n-propylnorapomorphine as an internal standard is described. The molecular ions of the TMS derivatives of apomorphine (m/z 411) and N-n-propylnorapomorphine (m/z 439) were assayed simultaneously by selected ion monitoring. Sensitivity was 30 ng per ml plasma. The results obtained by plasma apomorphine concentration time course study in rats suggested that this method was applicable to pharmacokinetic studies for apomorphine.
描述了一种以N-正丙基去甲阿扑吗啡为内标物的阿扑吗啡选择离子监测测定法。通过选择离子监测同时测定阿扑吗啡（m/z 411）和N-正丙基去甲阿扑吗啡（m/z 439）的TMS衍生物的分子离子。灵敏度为每毫升血浆30纳克。通过大鼠血浆阿扑吗啡浓度时间进程研究获得的结果表明，该方法适用于阿扑吗啡的药代动力学研究。
