Pickartz H, Moltz L, Altenähr E
Virchows Arch A Pathol Anat Histol. 1980;389(1):103-17. doi: 10.1007/BF00428671.
The gonads of 4 phenotypically female individuals with XY chromosomal constitution and signs of virilisation were examined by light microscopy. Electron microscopic examination was also performed in two cases. Serological analysis of H-Y antigen titer yielded positive results. The matrix of the gonads is shown to be ovarian stroma, in which tubular and follicular structures are embedded. The epithelia of the follicles resemble granulosa cells of the ovary, the tubular epithelia are resemble Sertoli cells. Tubules and follicles both show extensive regressive changes. A varying number of Leyding cells/stroma lutein cells were found in each gonad. The different degree of development of testicular and ovarian structures in the dysgenetic gonads might be explained by a defect of the gonadal specific receptor for the H-Y antigen, this defect varying in time of occurrence, duration and severity.
对4名具有XY染色体构成且有男性化体征的表型女性个体的性腺进行了光学显微镜检查。其中两例还进行了电子显微镜检查。H-Y抗原滴度的血清学分析结果呈阳性。性腺基质显示为卵巢基质，其中包埋有管状和滤泡状结构。滤泡上皮类似于卵巢的颗粒细胞，管状上皮类似于支持细胞。小管和滤泡均显示出广泛的退行性变化。每个性腺中均发现了数量不等的睾丸间质细胞/基质黄体化细胞。发育不全性腺中睾丸和卵巢结构的不同发育程度可能是由于H-Y抗原性腺特异性受体缺陷所致，这种缺陷在发生时间、持续时间和严重程度上各不相同。
