Davis J D, Wirtshafter D, Asin K E, Brief D
Science. 1981 Apr 3;212(4490):81-3. doi: 10.1126/science.7193909.
Long-term infusion of glucose, beta-hydroxybutyrate, and glycerol into the third ventricle of the rat brain caused a stabilization of body weight at a lower than normal level. Among the glucose- and glycerol-treated animals this weight loss was caused in part by temporary hypophagia. Among the animals treated with beta-hydroxybutyrate the weight loss was unaccompanied by a reduction in food intake. The results are consistent with the view that the systems controlling food intake and body weight are sensitive to the availability of brain fuels. They are not consistent however, with the view that these control systems monitor calories independently of their source.
向大鼠脑的第三脑室长期输注葡萄糖、β-羟基丁酸酯和甘油会使体重稳定在低于正常水平。在接受葡萄糖和甘油治疗的动物中，体重减轻部分是由暂时的食欲减退引起的。在接受β-羟基丁酸酯治疗的动物中，体重减轻并未伴随食物摄入量的减少。这些结果与控制食物摄入和体重的系统对脑内燃料可用性敏感这一观点一致。然而，它们与这些控制系统独立于热量来源监测卡路里的观点不一致。
