Perlow M J, Reppert S M, Boyar R M, Klein D C
Neuroendocrinology. 1981 Apr;32(4):193-6. doi: 10.1159/000123157.
Cerebrospinal fluid was continuously collected from the cisternal-cervical subarachnoid space of chair-restrained rhesus monkeys. The concentrations of melatonin and cortisol were measured in the cerebrospinal fluid. Under diurnal lighting (light:dark, 12:12 h) melatonin concentrations were elevated during darkness and low during illumination. The melatonin rhythm persisted in constant darkness but was suppressed in constant illumination. Under diurnal lighting, cortisol concentrations were elevated in the early portion of the light period. This daily rhythmicicty of cortisol secretion was not altered by constant illumination or constant darkness. The differential response of the two hormones to constant light suggest that the daily fluctuation of melatonin secretion was not responsible for the daily rhythmicity of cortisol secretion in the rhesus monkey.
从用椅子固定的恒河猴的枕颈蛛网膜下腔连续采集脑脊液。测量脑脊液中褪黑素和皮质醇的浓度。在昼夜光照（光照：黑暗，12:12小时）条件下，褪黑素浓度在黑暗期间升高，在光照期间降低。褪黑素节律在持续黑暗中持续存在，但在持续光照中受到抑制。在昼夜光照条件下，皮质醇浓度在光照期的早期升高。皮质醇分泌的这种每日节律不受持续光照或持续黑暗的影响。两种激素对持续光照的不同反应表明，褪黑素分泌的每日波动与恒河猴皮质醇分泌的每日节律无关。
