Ziats N P, Robertson A L
Atherosclerosis. 1981 Feb-Mar;38(3-4):401-10. doi: 10.1016/0021-9150(81)90056-3.
Incubated human peripheral blood monocytes release a factor(s) which specifically stimulates homologous vascular smooth muscle (SMC) but not endothelial cells (EC) to proliferate in vitro. Conditioned medium from activated monocytes significantly (P less than 0.001) stimulated proliferation of SMC within 6 days of culture while media from non-activated monocytes was less effective (P less than 0.01). Non-vascular smooth muscle cells (human myometrium) were less responsive to such media (P less than 0.01 and P less than 0.05, respectively). These findings suggest that blood monocytes may play a key and until now unsuspected role in arterial smooth muscle proliferation, a recognized event in the initial stages of atherogenesis.
培养的人外周血单核细胞释放一种因子，该因子能特异性刺激同源血管平滑肌（SMC）而非内皮细胞（EC）在体外增殖。活化单核细胞的条件培养基在培养6天内显著（P<0.001）刺激SMC增殖，而非活化单核细胞的培养基效果较差（P<0.01）。非血管平滑肌细胞（人子宫肌层）对这类培养基反应较弱（分别为P<0.01和P<0.05）。这些发现表明，血液单核细胞可能在动脉平滑肌增殖中发挥关键且迄今未被怀疑的作用，动脉平滑肌增殖是动脉粥样硬化发生初始阶段的一个公认事件。
