血浆纤连蛋白对人单核细胞/巨噬细胞衍生生长因子（MDGF）产生的刺激作用。
Stimulation of human monocyte/macrophage-derived growth factor (MDGF) production by plasma fibronectin.
作者信息
Martin B M, Gimbrone M A, Majeau G R, Unanue E R, Cotran R S
出版信息
Am J Pathol. 1983 Jun;111(3):367-73.
Abstract
Culture supernatants from human peripheral blood monocytes, isolated free of platelet contamination and cultured in the absence of serum, stimulate DNA synthesis and cell growth in Balb/c 3T3 fibroblasts and bovine aortic smooth-muscle cells. Monocytes cultured in serum-free medium for 24 hours with plasma fibronectin, added as either a surface-attached or soluble molecule, secrete significantly increased amounts of growth-promoting activity. Fibronectin also stimulates an increase in intracellular growth factor content and in protein synthesis by monocytes. Both the enhanced growth-promoting activity and protein synthesis are inhibited by cycloheximide. Thus, fibronectin-monocyte interactions may influence the production of growth-promoting activity by monocytes and contribute to fibroblast and smooth-muscle replication in wound healing, chronic inflammation and atherosclerosis.
摘要
从人外周血单核细胞中分离出的培养上清液，在无血小板污染且无血清的条件下培养，可刺激Balb/c 3T3成纤维细胞和牛主动脉平滑肌细胞的DNA合成及细胞生长。在无血清培养基中培养24小时的单核细胞，添加作为表面附着分子或可溶性分子的血浆纤连蛋白后，分泌的促生长活性物质显著增加。纤连蛋白还能刺激单核细胞内生长因子含量增加及蛋白质合成增加。环己酰亚胺可抑制增强的促生长活性和蛋白质合成。因此，纤连蛋白与单核细胞的相互作用可能影响单核细胞促生长活性的产生，并有助于伤口愈合、慢性炎症和动脉粥样硬化中纤维母细胞和平滑肌的增殖。
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本文引用的文献
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