Cwern M, Garcia R L, Davidson M I, Friedman I H
Am J Gastroenterol. 1981 Jan;75(1):41-7.
Gastric carcinoma is a rare entity in twins at any age. A 31-year old black male presented with a nine-month history of epigastric pain and was found to have cancer of the stomach. His asymptomatic twin was therefore evaluated and also found to have gastric carcinoma. Both patients underwent gastric resection. Pathologically the cancers were similar, although the associated changes of the gastric mucosa showed some remarkable differences. The uniqueness of carcinoma in twins has resulted in extensive utilization of twin studies in an attempt to clarify genetic, environmental and immunological factors in the development of cancer. The results of these studies reported in the literature, however, are inconclusive. Gastric cancer is quite uncommon in the younger population but must be promptly excluded when symptoms doe not quickly respond to usual therapy.
胃癌在任何年龄段的双胞胎中都是一种罕见的病症。一名31岁的黑人男性因上腹部疼痛九个月前来就诊，被诊断患有胃癌。因此，对其无症状的双胞胎进行了评估，结果发现也患有胃癌。两名患者均接受了胃切除术。病理检查显示，虽然胃癌相关的胃黏膜变化存在一些显著差异，但这两种癌症在病理上相似。双胞胎患癌的独特性促使人们广泛开展双胞胎研究，试图阐明癌症发生过程中的遗传、环境和免疫因素。然而，文献中报道的这些研究结果尚无定论。胃癌在年轻人群中相当罕见，但当症状对常规治疗没有迅速反应时，必须及时排除胃癌的可能。
