Jayanthi M, Habibullah C M, Ishaq M, Ali H, Babu P S, Ali M M
Department of Gastroenterology, Osmania General Hospital, Hyderabad, India.
J Med Genet. 1989 Mar;26(3):172-3. doi: 10.1136/jmg.26.3.172.
Haptoglobin (Hp) phenotypes were studied in 72 oesophageal and 104 gastric cancer patients and compared with 100 healthy controls to see if there is any association between oesophageal and gastric cancer and haptoglobin type. There was a significantly increased frequency of Hp 2-1 (59.7%) and Hp 2-2 (91.3%) in oesophageal and gastric cancer patients. Our results suggest that genetic factors play a role in the aetiology and pathogenesis of gastrointestinal tract malignancy.
对72例食管癌患者和104例胃癌患者的触珠蛋白（Hp）表型进行了研究，并与100名健康对照者进行比较，以观察食管癌、胃癌与触珠蛋白类型之间是否存在关联。食管癌和胃癌患者中Hp 2-1（59.7%）和Hp 2-2（91.3%）的频率显著增加。我们的结果表明，遗传因素在胃肠道恶性肿瘤的病因学和发病机制中起作用。
