Górka Z, Wojtasik E
Pol J Pharmacol Pharm. 1980 Jul-Aug;32(4):463-8.
A possibility of inducing immobility in rats immersed in a cylinder filled with water from which they cannot escape was confirmed. The period of active attempts to escape from the cylinder was lengthened by injecting the animals with the following antidepressants: imipramine (IMI), amitriptyline (AMI), doxepin (DOS), mianserin (MIA), danitracen (DAN), iprindole (IPR), as well as cyproheptadine (CYP), even if they were administered only once. Femoxetine (FEM) produces no effect,. The swimming activity of rats diminished gradually to ca 15% of the initial value if experiments were repeated during 7-8 consecutive days. A chronic administration of IMI in a dose of 10mg/kg daily counteracted this phenomenon, and when the drug had been given for 10 days before the immersions were started, it presented the decrease in the activity.
已证实存在一种可能性，即能使浸入装满水且无法逃脱的圆筒中的大鼠出现不动状态。给动物注射以下抗抑郁药可延长其主动尝试从圆筒中逃脱的时间：丙咪嗪（IMI）、阿米替林（AMI）、多塞平（DOS）、米安色林（MIA）、达尼曲辛（DAN）、茚满二氮卓（IPR），以及赛庚啶（CYP），即便仅给药一次也有此效果。非莫西汀（FEM）则无此作用。如果连续7 - 8天重复进行实验，大鼠的游泳活动会逐渐减少至初始值的约15%。每日以10mg/kg的剂量长期给予丙咪嗪可抵消这一现象，并且在开始浸入实验前10天给予该药物时，其活动量会出现下降。
