Kwiatkowska-Patzer B, Herbaczyńska-Cedro K
Arzneimittelforschung. 1981;31(6):959-61.
The effect of acetylsalicylic acid (ASA, Aspisol) upon diastolic threshold and refractory period in normal myocardium was investigated in the experiments on cats. It has been found that ASA given in a dose of 7 mg/kg i.v. significantly prolongs refractory period up to 27.7% of initial value throughout 2 h or observation. No significant changes in diastolic threshold were detected. Since the prolongation of refractory period favours stabilisation of cardiac rhythm, this effect of ASA may contribute to antiarrhythmic action of this drug observed earlier by other authors.
在猫身上进行的实验研究了乙酰水杨酸（ASA，阿斯匹林）对正常心肌舒张阈值和不应期的影响。结果发现，静脉注射7mg/kg剂量的ASA在整个2小时的观察期内可使不应期显著延长，达到初始值的27.7%。未检测到舒张阈值有显著变化。由于不应期的延长有利于心律的稳定，ASA的这种作用可能有助于其他作者先前观察到的该药物的抗心律失常作用。
