Magness R R, Huie J M, Hoyer G L, Huecksteadt T P, Reynolds L P, Seperich G J, Whysong G, Weems C W
Prostaglandins Med. 1981 Apr;6(4):389-401. doi: 10.1016/0161-4630(81)90071-9.
The relationship between the chronic intrauterine injection of PGE2 every four hours adjacent or opposite to the corpus luteum on luteal function was studied. Intrauterine infusions every four hours of PGE2 (500 mug) from days 10 to 17 postestrus maintained luteal function only when infused into a uterine horn adjacent to a luteal-bearing ovary of unilaterally ovariectomized sheep with surgically separated uterine cornua. These data are compatible with the hypothesis that PGE2 is a good candidate for the antiluteolysin since it works only through a similar local pathway as the embryo during early pregnancy to sustain the corpus luteum.
研究了每四小时在黄体相邻或相对处慢性子宫内注射前列腺素E2（PGE2）对黄体功能的影响。在发情后第10至17天，每四小时向单侧卵巢切除且子宫角手术分离的绵羊子宫角内注入500微克PGE2，只有当注入与有黄体的卵巢相邻的子宫角时，才能维持黄体功能。这些数据与以下假设相符，即PGE2是抗黄体溶解素的良好候选者，因为它仅通过与妊娠早期胚胎相似的局部途径起作用来维持黄体。
