血卟啉在体外培养的人细胞系NHIK 3025整个细胞周期中的光动力效应。
Photodynamic effect of haematoporphyrin throughout the cell cycle of the human cell line NHIK 3025 cultivated in vitro.
作者信息
Christensen T, Moan J, Wibe E, Oftebro R
出版信息
Br J Cancer. 1979 Jan;39(1):64-8. doi: 10.1038/bjc.1979.8.
Abstract
Cells from the established cell line NHIK 3025 were synchronized by repeated mitotic selections. Survival of the synchronized cells after treatment with haematoporphyrin and near-UV light was measured by testing the capacity of the cells to form macroscopic colonies. The sensitivity to photodynamic inactivation was small in early G1, late S and G2. The sensitivity increased throughout late G1 and early S to a maximum in mid S. More than a 100-fold variation is found in the survival after 20 min irradiation in the presence of 4 X 10(-4)M haematoporphyrin.
摘要
来自已建立的NHIK 3025细胞系的细胞通过重复的有丝分裂选择进行同步化。用血卟啉和近紫外光处理后，通过测试细胞形成肉眼可见菌落的能力来测量同步化细胞的存活率。在G1早期、S后期和G2期，对光动力失活的敏感性较小。在整个G1后期和S早期，敏感性增加，在S中期达到最大值。在存在4×10(-4)M血卟啉的情况下照射20分钟后，存活率发现有超过100倍的变化。
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引用本文的文献
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Br J Cancer. 1979 Apr;39(4):398-407. doi: 10.1038/bjc.1979.72.
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