Mathur S, Baker E R, Williamson H O, Derrick F C, Teague K J, Fudenberg H H
Fertil Steril. 1981 Oct;36(4):486-95.
Sperm antibody (AB) titers, determined by passive hemagglutination and cytotoxicity assays, were found to be elevated in 62 males and 46 females of 103 couples with primary infertility; 15 males and 12 females of 25 couples with secondary infertility; 10 males and 8 females of 18 couples with histories of repeated abortion; 21 males and 17 females of 25 couples in which the husband had a history of prostatitis; and 29 males and 17 females of 38 couples in which the husband had oligospermia. Of the couples in which one or both partners had elevated sperm AB titers, only 4 achieved pregnancy: 3 from the group with secondary infertility, all of which ended in spontaneous abortions, and 1 in which the husband was oligospermic. This suggests an etiologic role of sperm immunity in infertility. Immunosuppressive treatment of autoimmune males with prednisone (15 mg/day for 3 weeks to 6 months) resulted in significant decreases in AB titers. Pregnancies were achieved by 9 of 25 couples after treatment (36%). The observed increase in pregnancy rate in the prednisone-treated versus untreated groups of couples with elevated sperm AB titers was significant (P less than 0.02).
通过被动血凝试验和细胞毒性试验测定发现，在103对原发性不孕夫妇中，62名男性和46名女性的精子抗体（AB）滴度升高；在25对继发性不孕夫妇中，15名男性和12名女性的精子抗体滴度升高；在18对有反复流产史的夫妇中，10名男性和8名女性的精子抗体滴度升高；在25对丈夫有前列腺炎病史的夫妇中，21名男性和17名女性的精子抗体滴度升高；在38对丈夫患有少精子症的夫妇中，29名男性和17名女性的精子抗体滴度升高。在一方或双方伴侣精子AB滴度升高的夫妇中，只有4例成功怀孕：3例来自继发性不孕组，均以自然流产告终，1例丈夫为少精子症患者。这表明精子免疫在不孕中起病因学作用。用泼尼松（15毫克/天，持续3周至6个月）对自身免疫性男性进行免疫抑制治疗，可使AB滴度显著降低。治疗后，25对夫妇中有9对成功怀孕（36%）。在精子AB滴度升高的夫妇中，泼尼松治疗组与未治疗组相比，观察到的妊娠率增加具有显著性（P小于0.02）。
