Hargreave T B, Elton R A
Fertil Steril. 1982 Nov;38(5):586-90. doi: 10.1016/s0015-0282(16)46639-2.
Thirty-four men received steroid therapy in an attempt to overcome antisperm antibodies. Fifteen men received intermittent methylprednisolone (MP), 7 men received intermittent betamethasone following a failed course of MP, and 12 men received intermittent betamethasone. The pregnancy rate following steroid treatment, when compared with the expected pregnancy rate for patients with similar duration of infertility, was significantly improved. The titers of antibodies fell during steroid treatment. There were steroid side effects in all groups, although these were less marked in the group that received betamethasone alone. This work provides evidence that steroid treatment alters the expected prognosis and indicates that there is justification for a randomized trial in spite of the risks of treatment.
34名男性接受了类固醇疗法，试图克服抗精子抗体。15名男性接受间歇性甲基泼尼松龙（MP）治疗，7名男性在MP疗程失败后接受间歇性倍他米松治疗，12名男性接受间歇性倍他米松治疗。与不育时间相似的患者的预期妊娠率相比，类固醇治疗后的妊娠率显著提高。在类固醇治疗期间，抗体滴度下降。所有组都出现了类固醇副作用，尽管在仅接受倍他米松治疗的组中这些副作用不太明显。这项研究提供了证据表明类固醇治疗改变了预期的预后，并表明尽管存在治疗风险，但进行随机试验是有道理的。
