内源性决定因素对细胞形态的特异性调控
Specification of cell morphology by endogenous determinants.
作者信息
Solomon F
出版信息
J Cell Biol. 1981 Sep;90(3):547-53. doi: 10.1083/jcb.90.3.547.
Abstract
We are studying the mechanisms by which cells elaborate their differentiated morphologies. Here we discuss one aspect of this issue: the specification of the detailed shape of individual cells. We describe an experimental system in which endogenous determinants of morphology are expressed. These determinants originally were detected in the morphological relationships between sister neuroblastoma cells. Approaches to analyzing these relationships are presented. The properties and behavior of the endogenous determinants have been partially characterized by further experiments, which are also described. The significance and the prospects for further analysis of our findings are discussed.
摘要
我们正在研究细胞形成其分化形态的机制。在此，我们讨论这个问题的一个方面：单个细胞详细形状的确定。我们描述了一个表达形态学内源性决定因素的实验系统。这些决定因素最初是在神经母细胞瘤姐妹细胞之间的形态学关系中检测到的。本文介绍了分析这些关系的方法。通过进一步实验，对这些内源性决定因素的特性和行为进行了部分表征，本文也对此进行了描述。我们还讨论了研究结果的意义以及进一步分析的前景。
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