Uriel J, Dupiers M, Rimbaut C, Buffe D
Br J Obstet Gynaecol. 1981 Dec;88(12):1229-32. doi: 10.1111/j.1471-0528.1981.tb01202.x.
Serum concentrations of sex steroid-binding protein (SBP) were measured by an immunodiffusion technique in a total of 133 samples from 70 healthy pregnant women, 18 puerperal women and 21 non-pregnant women. In 6 individuals, trends or serum SBP were established from multiple samples taken throughout pregnancy. Maternal serum SBP levels had increased significantly above base line values as early as by 10 weeks gestation, and attained a plateau between 25 and 30 weeks, at which time mean values were about 10-fold higher than the normal non-pregnant range, the levels then declined slightly towards term. Parallel measurements of dihydrotestosterone-binding capacity of SBP showed a good correlation between SBP content and biological activity. Six abnormal pregnancies were encountered in the present study, and in five of them the molar ratios of bound hormone to SBP concentration were much lower than the normal value, suggesting a reduced binding capacity of the protein for the hormone.
采用免疫扩散技术，对70名健康孕妇、18名产后妇女和21名非孕妇的共计133份样本测定了血清中性类固醇结合蛋白（SBP）的浓度。对6名个体，在整个孕期采集多份样本，确定了血清SBP的变化趋势。孕妇血清SBP水平早在妊娠10周时就已显著高于基线值，并在25至30周之间达到平台期，此时平均值约为正常非孕期范围的10倍，随后水平在足月时略有下降。对SBP的二氢睾酮结合能力进行的平行测量显示，SBP含量与生物活性之间具有良好的相关性。在本研究中遇到6例异常妊娠，其中5例结合激素与SBP浓度的摩尔比远低于正常值，提示该蛋白对激素的结合能力降低。
