Inazu N, Kogo H, Aizawa Y
Jpn J Pharmacol. 1981 Apr;31(2):237-41. doi: 10.1254/jjp.31.237.
Effects of gonadotropin and estrogen on the levels of prostaglandin (PG) in the rat ovary wer investigated. PGF content in rat ovary, as measured by radioimmunoassay, was slightly higher than that by bioassay using rat stomach fundus, although there was no statistically significant difference. PGE and PGF levels in rat ovary during the estrous cycle were lowest on the day of diestrus, PGE was of the highest level on the day of estrus, and PGF on the day of proestrus. Both PGE and PGF were increased 24 hours after treatment with pregnant mare serum gonadotropin on the first day of diestrus. PGE was increased about 2.5 fold and PGF about 2.3 fold. PGF was significantly increased 24 hours after treatment with estradiol on the first day of diestrus. These results suggest that gonadotropin may directly or indirectly regulate changes in ovarian PG content via actions of estrogen.
研究了促性腺激素和雌激素对大鼠卵巢中前列腺素（PG）水平的影响。通过放射免疫测定法测得的大鼠卵巢中PGF含量略高于使用大鼠胃底进行生物测定法测得的含量，尽管差异无统计学意义。在动情周期中，大鼠卵巢中的PGE和PGF水平在间情期当天最低，PGE在发情期当天最高，PGF在发情前期当天最高。在间情期第一天用孕马血清促性腺激素处理24小时后，PGE和PGF均升高。PGE升高约2.5倍，PGF升高约2.3倍。在间情期第一天用雌二醇处理24小时后，PGF显著升高。这些结果表明，促性腺激素可能通过雌激素的作用直接或间接调节卵巢PG含量的变化。
