Inazu N, Kogo H, Aizawa Y
Jpn J Pharmacol. 1981 Oct;31(5):809-13. doi: 10.1254/jjp.31.809.
The role of uterine tissue in the changes of rat ovarian prostaglandin (PG) content was investigated. PGE and PGF levels in rat ovary were decreased to about one-fourth of control levels by hysterectomy, when the contents were determined on the day of estrus 4 days after surgery. Both the PGE and PGF contents in diestrous ovary 10 to 14 days after hysterectomy tended to be decreased, as compared with those in intact control (diestrus), but not significant difference was observed. Administration of estradiol to hysterectomized rats on the day of diestrus increased neither PGE nor PGF levels. Also with the administration of pregnant mare serum gonadotropin, no increase in the PG contents was seen in the ovary of hysterectomized rats. The incorporation of 3H-arachidonic acid into the 3H-PGE and 3H-PGF fractions, expressed in terms of the organ, was much greater in the uterus than in the ovary. The incorporation of 3H-arachidonic acid into the 3H-PGE and 3H-PGF fractions in the ovary was higher on the day of estrus than on the day of diestrus. These results strongly suggest that the changes in the PG content in rat ovary may be regulated, at least in part, by uterine tissue.
