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中耳炎发病机制、诊断及治疗的最新进展

Recent advances in the pathogenesis, diagnosis, and management of otitis media.

作者信息

Bluestone C D

出版信息

Pediatr Clin North Am. 1981 Nov;28(4):727-55. doi: 10.1016/s0031-3955(16)34063-9.

DOI:10.1016/s0031-3955(16)34063-9
PMID:7198219
Abstract
  1. Otitis media is one of the most common diseases of childhood. 2. Pathogenesis is related to eustachian tube dysfunction. 3. Etiology is primarily bacterial (S. pneumoniae, 40 per cent; H. influenzae, 20 per cent). Bacteria are also present in chronic otitis media with effusion ("secretory otitis"). 4. H. Influenzae is present in all age groups, and 15 to 30 per cent are ampicillin-resistant. 5. Diagnosis is by pneumatic otoscopy, or tympanometry, or both. 6. Tympanocentesis and/or myringotomy is important diagnostic-therapeutic procedure in selected patients. 7. Ampicillin (or amoxicillin) is initial therapy of choice. 8. Erythromycin and sulfonamide, trimethoprim-sulfamethoxazole, or cefaclor is recommended for those who have poor clinical response to initial antimicrobial therapy. 9. Efficacy is yet to be shown for antimicrobial prophylaxis, decongestants, antihistamines, myringotomy and tympanostomy tubes, and adenoidectomy with or without tonsillectomy. 10. Attendant conductive hearing loss is probably related to abnormalities in cognition, language, and learning.
摘要
  1. 中耳炎是儿童期最常见的疾病之一。2. 发病机制与咽鼓管功能障碍有关。3. 病因主要是细菌(肺炎链球菌,40%;流感嗜血杆菌,20%)。细菌也存在于分泌性中耳炎(“分泌性中耳炎”)中。4. 流感嗜血杆菌在所有年龄组中均有存在,15%至30%对氨苄西林耐药。5. 通过鼓气耳镜检查、鼓室图检查或两者进行诊断。6. 鼓膜穿刺术和/或鼓膜切开术对部分患者是重要的诊断治疗方法。7. 氨苄西林(或阿莫西林)是首选的初始治疗药物。8. 对于初始抗菌治疗临床反应不佳的患者,推荐使用红霉素、磺胺类药物、甲氧苄啶 - 磺胺甲恶唑或头孢克洛。9. 抗菌药物预防、减充血剂、抗组胺药、鼓膜切开术和鼓膜造孔管置入术以及腺样体切除术(伴或不伴扁桃体切除术)的疗效尚未得到证实。10. 随之而来的传导性听力损失可能与认知、语言和学习方面的异常有关。

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1
Recent advances in the pathogenesis, diagnosis, and management of otitis media.中耳炎发病机制、诊断及治疗的最新进展
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