Klawans H L, Glantz R, Tanner C M, Goetz C G
Neurology. 1982 Feb;32(2):203-6. doi: 10.1212/wnl.32.2.203.
Progressive difficulty in handwriting due to jerking movements precipitated by the act of writing beginning between the ages of 8 to 54 is reported in six patients. There was no rest tremor, but three had mild postural tremor. Specific muscle activity (especially pronation of the wrist or abduction of the fingers) elicited the tremors that persisted as long as the evocative posture or muscle activity was maintained. None had a family history of tremors, but two had a history suggestive of hypoxia at birth. Unlike benign essential tremor, the movements did not respond to propranolol HCl, but most patients were benefited both acutely and chronically by centrally active anticholinergic agents.
据报道，6例患者在8至54岁开始出现因书写动作引发的抽搐运动而导致的进行性书写困难。无静止性震颤，但3例有轻度姿势性震颤。特定的肌肉活动（尤其是手腕旋前或手指外展）会引发震颤，只要保持诱发姿势或肌肉活动，震颤就会持续。均无震颤家族史，但2例有出生时缺氧的病史。与良性特发性震颤不同，这些运动对盐酸普萘洛尔无反应，但大多数患者通过中枢性抗胆碱能药物获得了急性和慢性益处。
