Clandinin M T, Yamashiro S
J Nutr. 1982 Apr;112(4):825-8. doi: 10.1093/jn/112.4.825.
Histological study of ventricular muscle was conducted on Sprague-Dawley male rats fed diets containing 20% (w/w) of either soybean oil, low erucic acid rapeseed oil or high erucic acid rapeseed oil. Purified diets providing two levels of intake for choline and inositol or magnesium were fed for 16 weeks to determine whether increased intake of these nutrients reduced myocardial lesion incidence. Diets containing high erucic acid rapeseed oil resulted in a high incidence of degenerative focal myocardial lesions, whereas low erucic acid rapeseed oil feeding resulted in less severe cardiopathological changes. Dietary supplementation providing 0.475% (w/w) choline and 0.635% (w/w) inositol reduced incidence of myocardial lesion for both rapeseed oil treatments indicating that lesion incidence may also be altered by the nutrient composition of the purified diet. Nutritional adaptation by increasing the animals dietary fat intake from 6% (w/w) to 20% (w/w) over an 8-week period had no effect on lesion incidence.
对食用含20%（重量/重量）大豆油、低芥酸菜籽油或高芥酸菜籽油饮食的雄性Sprague-Dawley大鼠进行了心室肌组织学研究。提供两种胆碱、肌醇或镁摄入量水平的纯化饮食喂养16周，以确定这些营养素摄入量的增加是否会降低心肌病变发生率。含高芥酸菜籽油的饮食导致退行性局灶性心肌病变的高发生率，而喂食低芥酸菜籽油导致的心脏病理变化较轻。提供0.475%（重量/重量）胆碱和0.635%（重量/重量）肌醇的膳食补充剂降低了两种菜籽油处理的心肌病变发生率，表明病变发生率也可能因纯化饮食的营养成分而改变。在8周内将动物饮食脂肪摄入量从6%（重量/重量）增加到20%（重量/重量）的营养适应对病变发生率没有影响。
