Evseev V A, Basharova L A, Vetrilé L A, Trekova N A, Mikovskaia O I
Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Jan-Feb;46(1):129-36.
The antibodies to serotonin modulate behavioural reactions of animals depending on the mode of administration (intracerebroventricular or intraperitoneal) and the testing time. Intraventricular injection induces inhibition of behavioural activity within 1--2 hours. Systemic injection produces a biphasic effect on the serotoninergic system, i. e., the activation in the early period and the steady inhibition later. Effects of the intraperitoneally injected serotonin antibodies on the CNS are probably mediated either by serotonin binding in blood or by involvement of neurotrophic factors of the immune system. Both ways of administration of the serotonin antibodies result in late hyperalgesia.
血清素抗体对动物行为反应的调节取决于给药方式（脑室内或腹腔内）和测试时间。脑室内注射在1-2小时内会抑制行为活动。全身注射对血清素能系统产生双相作用，即早期激活，后期持续抑制。腹腔注射血清素抗体对中枢神经系统的影响可能是通过血液中血清素的结合或免疫系统神经营养因子的参与介导的。血清素抗体的两种给药方式都会导致晚期痛觉过敏。
