Kraft L A, Polidoro J P, Culver R M, Hahn D W
Contraception. 1978 Sep;18(3):239-51. doi: 10.1016/s0010-7824(78)80018-3.
Solid (rod) and open (tube) prototype gole-platinum intravas device housings of three different surface designs were surgically inserted into the vasa deferentia of rabbits to test the feasibility of controlling male fertility. The devices were inserted through a short longitudinal slit in each vas deferens, secured with 4-0 silk suture and remained in situ for various periods ranging from 56--426 days. The solid devices completely inhibited the fertility of 6 rabbits in 20 of 21 matings. The fertile mating resulted after the loss of a device in one animal. In contrast, 7 of 9 rabbits receiving identical, but open (i.d. 0.8 mm), devices were fertile in numerous matings. Reduced sperm numbers or sperm-free ejaculates were usually obtained for 2--3 weeks after surgery, but returned to normal following this period. However, sperm blockage due to connective tissue infiltration and eventual encapsulation of the open devices was subsequently observed in about 50% of the animals. Histological changes of the vas deferens at the sites of some of the devices included occasional sperm granulomas, mild focal submucosal edema, mucosal erosion and mild mucosal hyperplasia due to fibroblastic proliferation.
三种不同表面设计的实心（棒状）和开放式（管状）原型金铂输精管内装置外壳通过手术植入兔输精管，以测试控制雄性生育能力的可行性。这些装置通过在每个输精管上的短纵向切口插入，用4-0丝线缝合固定，并在原位保留56至426天不等的不同时间。21次交配中，实心装置在20次交配中完全抑制了6只兔子的生育能力。在一只动物的装置丢失后出现了一次可育交配。相比之下，9只接受相同但开放式（内径0.8毫米）装置的兔子中有7只在多次交配中可育。术后2至3周通常会出现精子数量减少或无精子射精，但在此之后会恢复正常。然而，随后在约50%的动物中观察到开放式装置因结缔组织浸润和最终被包裹而导致精子堵塞。一些装置部位的输精管组织学变化包括偶尔出现的精子肉芽肿、轻度局灶性黏膜下水肿、黏膜糜烂以及因成纤维细胞增殖导致的轻度黏膜增生。
