Brueschke E E, Wingfield J R, Zaneveld L J
Invest Urol. 1976 Mar;13(5):359-65.
In contrast to the results that were obtained with rigid ended prosthetic devices, effective sperm transport occurred for prolonged periods of time through the IITRI Vas-Valve, which had soft silicone rubber flexible end tubes when implanted in the vasa deferentia of dogs. Such transport could be halted by device occlusion with stainless steel springs or with shuttle stem valves. Opening the devices resulted once more in the passage of spermatozoa as well as the production of offspring, indicating that these devices have the potential for being useful as a human male contraceptive method. More research needs to be performed to determine why there is an over-all decrease in sperm output after device implantation and to evaluate and adverse side effects of such devices. The presence of Dacron velour-covered suture rings on the devices permitted effective tissue ingrowth and prevented leakage or recanalization in all cases.
与刚性末端假体装置所获得的结果相反，当IITRI输精管瓣膜植入狗的输精管时，由于其末端软管采用柔软的硅橡胶材质，精子能够长时间有效地运输。通过使用不锈钢弹簧或穿梭式杆状瓣膜阻塞该装置，这种运输可以停止。打开装置后，精子再次通过并产生后代，这表明这些装置有潜力成为一种人类男性避孕方法。需要进行更多的研究来确定装置植入后精子产量总体下降的原因，并评估此类装置的不良副作用。装置上的涤纶丝绒覆盖缝合环能使组织有效向内生长，并在所有情况下防止渗漏或再通。
