氟芬那酸和依托芬那酯的核羟基化衍生物的合成与性质（作者译）
[Synthesis and properties of nuclear hydroxylated derivatives of flufenamic acid and etofenamate (author's transl)].
作者信息
Boltze K H, Bäcker U, Kreisfeld H
出版信息
Arzneimittelforschung. 1982;32(3):183-6.
PMID:7200776
Abstract
Synthesis of six nuclear hydroxylated derivatives of flufenamic acid and etofenamate (5-OH-, 4'-OH and 5,4'-(OH2) on a preparative scale is described. All compounds show low toxicity, but only weak anti-inflammatory activity in the rat paw kaolin edema test as compared to 2-(2-hydroxyethoxy)ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate, active substance of Rheumon Gel).
摘要
描述了氟芬那酸和依托芬那酯六种核羟基化衍生物（5-OH-、4'-OH和5,4'-(OH)₂）的制备规模合成。所有化合物毒性低，但与2-(2-羟基乙氧基)乙基-N-(α,α,α-三氟间甲苯基)邻氨基苯甲酸酯（依托芬那酯，风湿凝胶的活性物质）相比，在大鼠足高岭土水肿试验中抗炎活性较弱。
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