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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jacobi H, Breier P, Dell H D, Lorenz D

Arzneimittelforschung. 1977;27(6B):1326-33.

The reliable antiphlogistic action of 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate active principle of Rheumon Gel) in various experimental inflammatory models in animals is demonstrated following oral and cutaneous administration. 2. The proven inhibition of inflammatory edema by chronic administration of Rheumon gel evidences the percutaneous absorption of the active principle through the intact skin. 3. The effect of Rheumon gel sets in independently of whether the gel is applied to normal or to pathologically inflamed tissue areas. 4. Gastrointestinal mucous tolerance is better for etofenamate than for flufenamic acid, phenylbutazone and other anti-inflammatory drugs.

2-(2-羟乙氧基)乙基-N-(α,α,α-三氟间甲苯基)邻氨基苯甲酸（风湿凝胶的活性成分依托芬那酯）经口服和皮肤给药后，在多种动物实验性炎症模型中显示出可靠的抗炎作用。2. 长期使用风湿凝胶对炎症性水肿的有效抑制证明了活性成分可透过完整皮肤经皮吸收。3. 无论将凝胶应用于正常组织区域还是病理炎症组织区域，风湿凝胶均能发挥作用。4. 依托芬那酯对胃肠道黏膜的耐受性优于氟芬那酸、保泰松及其他抗炎药物。

Jacobi H, Breier P, Dell H D, Lorenz D

Arzneimittelforschung. 1977;27(6B):1326-33.

The reliable antiphlogistic action of 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate active principle of Rheumon Gel) in various experimental inflammatory models in animals is demonstrated following oral and cutaneous administration. 2. The proven inhibition of inflammatory edema by chronic administration of Rheumon gel evidences the percutaneous absorption of the active principle through the intact skin. 3. The effect of Rheumon gel sets in independently of whether the gel is applied to normal or to pathologically inflamed tissue areas. 4. Gastrointestinal mucous tolerance is better for etofenamate than for flufenamic acid, phenylbutazone and other anti-inflammatory drugs.

2-(2-羟乙氧基)乙基-N-(α,α,α-三氟间甲苯基)邻氨基苯甲酸（风湿凝胶的活性成分依托芬那酯）经口服和皮肤给药后，在多种动物实验性炎症模型中显示出可靠的抗炎作用。2. 长期使用风湿凝胶对炎症性水肿的有效抑制证明了活性成分可透过完整皮肤经皮吸收。3. 无论将凝胶应用于正常组织区域还是病理炎症组织区域，风湿凝胶均能发挥作用。4. 依托芬那酯对胃肠道黏膜的耐受性优于氟芬那酸、保泰松及其他抗炎药物。