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氯乙烯所致肝纤维化进展为肝血管肉瘤。

Progression of vinyl chloride induced hepatic fibrosis to angiosarcoma of the liver.

作者信息

Jones D B, Smith P M

出版信息

Br J Ind Med. 1982 Aug;39(3):306-7. doi: 10.1136/oem.39.3.306.

Abstract

ABSTRACT Two vinyl chloride monomer (VCM) workers, who developed non-cirrhotic portal fibrosis and portal hypertension, died from angiosarcoma of the liver five and ten years later respectively, despite withdrawal from occupational exposure. We suggest that non-cirrhotic portal fibrosis caused by exposure to VCM is potentially premalignant and that those workers who already have the condition should be carefully monitored.

摘要

摘要 两名氯乙烯单体(VCM)工人患上了非肝硬化性门脉纤维化和门脉高压症,尽管他们已不再接触职业性暴露因素,但分别在5年后和10年后死于肝血管肉瘤。我们认为,接触VCM所致的非肝硬化性门脉纤维化有潜在的恶变可能,应对已有此病症的工人进行密切监测。

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Vinylchloride induced hepatic angiosarcoma.氯乙烯诱发的肝血管肉瘤。
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本文引用的文献

4
Alkylation of DNA and proteins in mice exposed to vinyl chloride.接触氯乙烯的小鼠体内DNA和蛋白质的烷基化作用。
Biochem Biophys Res Commun. 1976 May 23;76(2):259-66. doi: 10.1016/0006-291x(77)90720-3.
6
Clinical and morphologic features of hepatic angiosarcoma in vinyl chloride workers.氯乙烯作业工人肝血管肉瘤的临床及形态学特征
Cancer. 1976 Jan;37(1):149-63. doi: 10.1002/1097-0142(197601)37:1<149::aid-cncr2820370122>3.0.co;2-7.
10
Portal hypertension in vinyl-chloride production workers.氯乙烯生产工人的门静脉高压症
Lancet. 1976 Sep 18;2(7986):602-4. doi: 10.1016/s0140-6736(76)90668-1.

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