正常男性血清非结合胆汁酸的昼夜变化
Diurnal changes in serum unconjugated bile acids in normal man.
作者信息
Setchell K D, Lawson A M, Blackstock E J, Murphy G M
出版信息
Gut. 1982 Aug;23(8):637-42. doi: 10.1136/gut.23.8.637.
Abstract
Unconjugated bile acids were measured using gas chromatography-mass spectrometry in the serum of two subjects throughout a 24 hour period and in two other subjects over a six hour period after breakfast. Unconjugated bile acids were found in all samples of serum and included cholic, chenodeoxycholic, deoxycholic, 3 beta, 7 alpha-dihydroxy-5 beta-cholanic (iso-chenodeoxycholic), ursodeoxycholic, 3 beta, 7 beta-dihydroxy-5 beta-cholanic (iso-ursodeoxycholic), 3 beta-hydroxy-5-cholenoic, and lithocholic acids. The maximum concentration of each bile acid generally occurred between breakfast and dinner and total unconjugated bile acid concentrations attained levels of between 2-3 mumol/l. Concentrations increased after breakfast and were often as high as 30-40% of the conjugated bile acid glycocholate, but returned to fasting levels in the absence of lunch. The intestinal absorption of unconjugated bile acids is therefore of greater quantitative importance than was previously thought.
摘要
在24小时内对两名受试者的血清以及另外两名受试者早餐后6小时内的血清，使用气相色谱 - 质谱法测定了游离胆汁酸。在所有血清样本中均发现了游离胆汁酸，包括胆酸、鹅去氧胆酸、脱氧胆酸、3β,7α - 二羟基 - 5β - 胆烷酸（异鹅去氧胆酸）、熊去氧胆酸、3β,7β - 二羟基 - 5β - 胆烷酸（异熊去氧胆酸）、3β - 羟基 - 5 - 胆烯酸和石胆酸。每种胆汁酸的最高浓度通常出现在早餐和晚餐之间，游离胆汁酸的总浓度达到2 - 3μmol/L。早餐后浓度升高，常常高达结合胆汁酸甘氨胆酸的30 - 40%，但在没有午餐的情况下会恢复到空腹水平。因此，游离胆汁酸的肠道吸收在数量上比之前认为的更为重要。
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