Warszawski D, Gorodischer R
Pediatr Pharmacol (New York). 1981;1(4):341-6.
Caffeine concentrations were measured in postmortem tissues of two premature infants who had received caffeine for the prevention of apnea. The distribution of caffeine was not uniform: Up to a 2.1-fold difference in caffeine concentrations existed among the various tissues in one infant and up tu a 4.3-fold difference in the other. This variability was only slightly reduced when caffeine concentrations were corrected for the water content of the respective tissues. Caffeine was also analyzed in tissues of newborn and adult dogs 3, 10, and 36 hr after single doses of caffeine (50 mg/kg IV). The decrease in caffeine concentrations was slower in the puppy than in the adult dog. The ratio tissue water caffeine/plasma water caffeine decreased with time after administration of this drug: It ranged between 0.9 and 1.1 at 3 hr and between 0.5 and 1.0 at 10 hr in adult dogs, and it varied from 0.8 to 1.3 at 3 hr and from 0.5 to 0.8 at 36 hr in puppies. Greater caffeine concentrations in newborn than in adult tissues following a given dose are consistent with the known slow elimination rate of caffeine in the young organism.
对两名接受咖啡因预防呼吸暂停的早产儿的死后组织进行了咖啡因浓度测量。咖啡因的分布并不均匀：一名婴儿的不同组织间咖啡因浓度存在高达2.1倍的差异，另一名婴儿则高达4.3倍。当根据各组织的含水量对咖啡因浓度进行校正后，这种变异性仅略有降低。还对新生犬和成年犬在单次静脉注射咖啡因（50mg/kg）后3、10和36小时的组织进行了咖啡因分析。幼犬体内咖啡因浓度的下降比成年犬慢。给药后，组织水咖啡因/血浆水咖啡因的比值随时间下降：成年犬在3小时时该比值在0.9至1.1之间，10小时时在0.5至1.0之间；幼犬在3小时时该比值在0.8至1.3之间，36小时时在0.5至0.8之间。在给予相同剂量后，新生组织中的咖啡因浓度高于成年组织，这与已知的咖啡因在幼体中的缓慢消除率一致。
