Giacoia G P, Jungbluth G L, Jusko W J
Saint Francis Hospital Medical Research Institute of Pediatrics, Tulsa Medical College, Okla.
Dev Pharmacol Ther. 1989;12(4):205-10.
The systemic absorption of orally administered caffeine was evaluated in 16 premature infants receiving therapy for recurrent apnea. An oral bolus dose of caffeine (10 mg/kg) was given during a fasted state (n = 8) or immediately preceding formula (n = 8). The first-order absorption rate constant (ka) was estimated from the rise in the plasma concentration-time curve and extent of absorption was estimated by the area under the concentration-time curve. Therapeutic concentrations of caffeine were achieved rapidly followed by very slow elimination of drug. No difference between the fasted and fed groups was found in the apparent rate or extent of caffeine absorption, suggesting that caffeine can be administered concomitantly with feedings.
在16名接受反复呼吸暂停治疗的早产儿中评估了口服咖啡因的全身吸收情况。在禁食状态下（n = 8）或紧接配方奶喂养前（n = 8）给予口服咖啡因大剂量（10 mg/kg）。根据血浆浓度-时间曲线的上升估计一级吸收速率常数（ka），并通过浓度-时间曲线下面积估计吸收程度。咖啡因迅速达到治疗浓度，随后药物消除非常缓慢。在咖啡因吸收的表观速率或程度方面，禁食组和喂食组之间未发现差异，这表明咖啡因可以与喂养同时给药。
