Tang S W, Helmeste D M, Stancer H C
Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):207-11. doi: 10.1007/BF00498812.
The effect of acute (single dose), short-term (4 days), and chronic treatment (21 days) with two tricyclic antidepressants desipramine and amitriptyline on brain 3-methoxy-4-hydroxyphenylglycol (MHPG) was examined in the rat. Amitriptyline had no effect on brain total MHPG irrespective of the duration of the treatment and did not interfere with the lowering effect of clonidine on brain total MHPG. Acute and short-term desipramine treatment decreased brain total MHPG in rats, while chronic desipramine treatment increased it. The differential effect of acute and chronic treatment of desipramine on the brain total MHPG was further demonstrated by the lack of interference with the lowering effect of clonidine on brain total MHPG by one single dose of desipramine; partial interference after 4 days and complete interference after 21 days of desipramine treatment.
研究了两种三环类抗抑郁药去甲丙咪嗪和阿米替林对大鼠脑内3-甲氧基-4-羟基苯乙二醇（MHPG）的急性（单次给药）、短期（4天）和慢性治疗（21天）的影响。无论治疗持续时间如何，阿米替林对脑内总MHPG均无影响，且不干扰可乐定对脑内总MHPG的降低作用。急性和短期去甲丙咪嗪治疗可降低大鼠脑内总MHPG，而慢性去甲丙咪嗪治疗则使其升高。单次剂量的去甲丙咪嗪对可乐定降低脑内总MHPG的作用无干扰，进一步证明了急性和慢性去甲丙咪嗪治疗对脑内总MHPG的不同影响；去甲丙咪嗪治疗4天后部分干扰，21天后完全干扰。
